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So I have content defined in my html as a div. If I add an event handler to an element in the div it seems to work the first time then if the tooltip hides and then shows the event doesn't work.
Tipped already adds events handlers for you through the showOn and hideOn options.
If you need to add your own event handlers. Create a tooltip with both showOn and hideOn set to false and use the API to control the display. You can use Tipped.show() and Tipped.hide() for this.
Ah wait I guess you mean in the tooltip. You could use the the afterUpdate callback on the tooltip to bind handlers.
Setting detach: false might also help, it keeps the tooltip content attached to the DOM at all times.
Cheers, that helps.